Jungholm Laboratories
Effects on the ion-channel TRPV1. Receptor facilitation and inhibition by varying concentrations of Agonist and Antagonist when ligand is applied, the [EC80]/[IC80] could be determined. Experiments were performed in a TRPV1-expressing cell-line.
Cell-based Assays & custom cell-lines
Our Cell-based Assay services—including viability, cytotoxicity, proliferation, and a variety of signaling assays—are built on a foundation of scientific rigor and quality assurance.
Whether you're screening compounds or validating mechanisms of action. We can express your target in a model cell line or use a cell line of your choice.
TRPV1 receptor activation by Capsaicin concentration gradient, the receptor activation was measured in the presence of agonist or antagonist on the TRPV1-expressing cell-line.
Phosphorylation of Akt in cancer cells, in response to immunotherapy
Apoptosis, Necrosis, and Viability of colon cancer cells in response to immunotherapy
Microscopy
We specialize in high-resolution microscopy tailored to pharmaceutical research and development. Our state-of-the-art imaging platforms and expert analysts ensure precise visualization of cellular mechanisms and drug effects in biological samples. With an artistic sense and rigorous adherence to the scientific method, we deliver trustworthy imagery everyone can admire.
Nanotube formed between two cancer cells
Custom Research Project
As creative thinkers, we are always excited to hear about innovative projects and bold thoughts. Do not hesitate to contact us, even if it is only to exchange ideas in an informal setting.
A laser was used to generate a local pulse of heat to activate the heat-sensitive TRPV1 ion channel in cells. Combined with a microfluidic pipette, designed to rapidly switch between several drug treatments in a confined set of cells allowed for determining both ligands and heat activation of this ion channel.