Our work speaks for itself.
“In-house protein production, coupled with robust binding assays gives the most bang for your buck”
To initiate a pharmacological investigation, it is essential to acquire large quantities of the drug target for various testing. Information on target binding such as dissociation constant (Kd) or crafting the optimal formulation (e.g. pH-dependent binding effects) requires the protein of interest and in our experience, lots of it. Therefore we are located in a protein-production facility where the target of interest can be produced in-house, vastly reducing the cost of a project.
We can perform Fluorescence polarization assays (Kd), ELISA (antibodies), FRET, ITC, and more.
Flow-cytometric evaluation of SARS-COV-2 binding antibodies against a cell-line over-expressing the spike-protein.
Mesoscale (MSD) evaluation of anti-SARS-COV-2 antibodies’ ability to block ACE2-binding from a battery of fragments from the spike protein.
Binding of a proprietary antibody on a Cell line over-expressing the receptor of interest (green).