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    <lastmod>2025-10-24</lastmod>
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    <loc>https://jungholmlabs.com/portfolio/project-two-ky966-axzx2</loc>
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    <lastmod>2026-04-02</lastmod>
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      <image:title>Portfolio - Imaging Projects and microscopy</image:title>
      <image:caption>Red Blood Cells seen through the eyepiece of a microscope</image:caption>
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      <image:title>Portfolio - Imaging Projects and microscopy</image:title>
      <image:caption>Internalization of fluorescent antibody into cancer cell, labels indicating its membrane in purple, nucleus in blue, endosome in red, and antibody in green.</image:caption>
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      <image:title>Portfolio - Imaging Projects and microscopy</image:title>
      <image:caption>Macropinocytosis marker (green) shows distinct regions in cells responsible for the uptake of large molecules.</image:caption>
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      <image:title>Portfolio - Imaging Projects and microscopy</image:title>
      <image:caption>Communication between cells via membrane nanotubes.</image:caption>
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      <image:title>Portfolio - Imaging Projects and microscopy</image:title>
      <image:caption>Cell line over-expressing the pain receptor TRPV1 (green).</image:caption>
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      <image:title>Portfolio - Imaging Projects and microscopy</image:title>
      <image:caption>3D rendering of a tumour organoid</image:caption>
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      <image:title>Portfolio - Imaging Projects and microscopy</image:title>
      <image:caption>Transportation of Fluorescently tagged antibody (green) in endosomes (red) within a cancer cell. Colocalization of antibody and endosome (red and green signal) is demonstrated as a histogram along a line of interest.</image:caption>
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      <image:title>Portfolio - Imaging Projects and microscopy</image:title>
      <image:caption>Identification of active macropinocytosis, with characteristical tent-pole formation and enveloping of the extracellular environment.</image:caption>
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      <image:title>Portfolio - Ion Channel Projects</image:title>
      <image:caption>Effects on the ion-channel TRPV1. Receptor facilitation and inhibition by Agonist or Antagonist, the [EC80]/[IC80] could be determined. Experiments were performed in a TRPV1-expressing cell-line.</image:caption>
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      <image:title>Portfolio - Ion Channel Projects</image:title>
      <image:caption>TRPV1 receptor activation by Capsaicin, the receptor activation was measured in the presence of agonist or antagonist on the TRPV1-expressing cell-line.</image:caption>
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    <image:image>
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      <image:title>Portfolio - Ion Channel Projects</image:title>
      <image:caption>A laser was used to generate a local pulse of heat to activate the heat-sensitive TRPV1 ion channel in an adherent cell culture. Combined with a microfluidic pipette, designed to rapidly switch between several drug treatments in a confined set of cells allowed for determining ligands as well as heat activation of this ion channel.</image:caption>
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      <image:title>Portfolio - Ion Channel Projects</image:title>
      <image:caption>Summary of inhibiting effects from commercial antagonists of TRPV1</image:caption>
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      <image:title>Portfolio - Ion Channel Projects</image:title>
      <image:caption>In-house developed method for investigating memory formation in live mouse hippocampus slices. This living brain tissue was subjected to the Glutamatergic agonist NMDA in a 96-well format and the Calcium influx to the neurons were recorded.</image:caption>
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      <image:title>Portfolio - Ion Channel Projects</image:title>
      <image:caption>In-house developed method for investigating memory formation in live mouse hippocampus slices. This living brain tissue was subjected to the Glutamatergic agonist NMDA in a 96-well format and the Calcium influx to the neurons were recorded.</image:caption>
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  <url>
    <loc>https://jungholmlabs.com/portfolio/project-one-f5w4d-z9nem-s3jda-eyssk-73f62-tmxz9-t4rx9-4kwj7</loc>
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    <lastmod>2026-04-01</lastmod>
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      <image:title>Portfolio - Oncology Projects</image:title>
      <image:caption>Apoptosis, Necrosis, and Viability of colon cancer cells in response to immunotherapy</image:caption>
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      <image:title>Portfolio - Oncology Projects</image:title>
      <image:caption>Phosphorylation of Akt in cancer cells, in response to immunotherapy</image:caption>
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      <image:title>Portfolio - Oncology Projects</image:title>
      <image:caption>Intracellular signaling cascade (ERK-pathway) inhibited by the MEK-inhibitor Trametinib in cancer cells. The phosphorylation of ERK is diminished in the cancer cell with increasing concentration of the drug.</image:caption>
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      <image:title>Portfolio - Custom Research Projects</image:title>
      <image:caption>Flow-cytometric evaluation of SARS-COV-2 binding antibodies against a cell-line over-expressing the spike-protein.</image:caption>
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      <image:title>Portfolio - Custom Research Projects</image:title>
      <image:caption>Mesoscale (MSD) evaluation of anti-SARS-COV-2 antibodies’ ability to block ACE2-binding from a battery of fragments from the spike protein.</image:caption>
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      <image:title>Portfolio - Custom Research Projects</image:title>
      <image:caption>Binding of a proprietary antibody on a Cell line over-expressing the receptor of interest (green).</image:caption>
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