Our work speaks for itself.
Take a look at a selection of our recent projects, crafted with care and designed to make an impact.
![Effects on the ion-channel TRPV1. Receptor facilitation and inhibition by Agonist or Antagonist, the [EC80]/[IC80] could be determined. Experiments were performed in a TRPV1-expressing cell-line.](https://images.squarespace-cdn.com/content/v1/68d14ec7fd99fb646c70c884/ea14f7f1-acd3-4761-b197-f80c79c87ecd/Baseline-corrected+of+Ab+IC_EC50.png)
Effects on the ion-channel TRPV1. Receptor facilitation and inhibition by Agonist or Antagonist, the [EC80]/[IC80] could be determined. Experiments were performed in a TRPV1-expressing cell-line.
TRPV1 receptor activation by Capsaicin, the receptor activation was measured in the presence of agonist or antagonist on the TRPV1-expressing cell-line.
A laser was used to generate a local pulse of heat to activate the heat-sensitive TRPV1 ion channel in an adherent cell culture. Combined with a microfluidic pipette, designed to rapidly switch between several drug treatments in a confined set of cells allowed for determining ligands as well as heat activation of this ion channel.
Summary of inhibiting effects from commercial antagonists of TRPV1
In-house developed method for investigating memory formation in live mouse hippocampus slices. This living brain tissue was subjected to the Glutamatergic agonist NMDA in a 96-well format and the Calcium influx to the neurons were recorded.
In-house developed method for investigating memory formation in live mouse hippocampus slices. This living brain tissue was subjected to the Glutamatergic agonist NMDA in a 96-well format and the Calcium influx to the neurons were recorded.